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The blunt lagging glass electrode tip cannot penetrate the brain tissue well and gives considerable pressure to the brain tissue, which is easy to cause greater trauma. Electrode sharpening can effectively reduce the damage to the brain tissue caused by the blunt glass electrode tip, and inject viruses, dyes or drugs into the target brain area more precisely. As shown in Figures A and B, the injection area can be precisely controlled to within 300 microns using this injection combination.

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◆ Shanghai Institute of Life Sciences, Chinese Academy of Sciences    ◆ Chengdu University of Traditional Chinese Medicine
◆ Shanghai University of Science and Technology    ◆ Zhejiang Xihu Advanced Research Institute
◆ USTC    ◆ Huazhong University of Science and Technology HUST
◆ Zhejiang University    ◆ Fudan University
◆ Tsinghua University    ◆ Institute of Biophysics, Chinese Academy of Sciences
◆ The Southern University of Science and Technology    ◆ Shenzhen Research Institute of Advanced Technology
◆ Beijing Institute of Life Sciences    ◆ University Of Qingdao
◆ The Fourth Military Medical University    ◆ Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
◆ The Army Military Medical University    ◆ Nanchang University
◆ Shanghai Institute of Advanced Studies, Chinese Academy of Sciences;    ◆ The Texas Agricultural Machinery University, USA